J Vet Clin 29(1) : 82-86 (2012)
Long-term Follow up after Implantation of Autologous Adipose
Tissue Derived Mesenchymal Stem Cells to Treat a Dog with
Stifle Joint Osteoarthrosis
Hun-Young Yoon，Jung-ha Lee and Soon-wuk Jeong’
Department 01 Veterinary Surgery yer College 01 Veterinary Medicine, and the Veterinary Science Research Institute，Konkuk University, SeouI143-701，Korea
(Accepted: February 17，2012)
Abstract :A 5-year-old castrated male Chihuahua weighing 1.54 kg was examined because of a several month history of progressive right hind limb lameness. Physical examination of the stifle joints revealed pain and a grade IV medial patellar luxation on the right stifle joint.The right and left stifle joints were associated with a lameness of grade 2 and grade 0，respectively. Radiography revealed osteophytes or subchondral cystic lesions on the right and left stifle joints. Osteoarthrosis (OA) scores for the right and left stifle joints were 20 and 12 respectively. Combination of surgery and implantation of autologous adipose tissue derived mesenchymal t stem cells (aAT-MSCs) was determined with informed consent. 1 x 10^6 aAT-MSCs suspended in PBS and 0.6mL of hyaluronic acid were injected in the right stifle joint postoperatively. Osteoarthrosis scores and the lameness grade for the right and left stifle joints were 19 and 13，and 0 and 01 9 months after treatment, respectively ,and 14 and 15，and 0 and 0 five years after treatment, respectively.
This case report shows radiographical evidence of a decrease in osteophytes and subchondral cystic lesions on the stifle joint with OA after aAT-MSCs injection.
Key words: Autologous adipose tissue-derived stem cells，stifle joint，osteoarthrosis，dog.