Long-term Follow up after Implantation of Autologous Adipose Tissue Derived Mesenchymal Stem Cells to Treat a Dog with Stifle Joint Osteoarthrosis

J Vet Clin 29(1) : 82-86 (2012)
 

Long-term Follow up after Implantation of Autologous Adipose

Tissue Derived Mesenchymal Stem Cells to Treat a Dog with
Stifle Joint Osteoarthrosis

Hun-Young YoonJung-ha Lee and Soon-wuk Jeong’

Department 01 Veterinary Surgery yer College 01 Veterinary Medicine, and the Veterinary Science Research InstituteKonkuk University, SeouI143-701Korea

(Accepted: February 172012)

Abstract :A 5-year-old castrated male Chihuahua weighing 1.54 kg was examined because of a several month history of progressive right hind limb lameness. Physical examination of the stifle joints revealed pain and a grade IV medial patellar luxation on the right stifle joint.The right and left stifle joints were associated with a lameness of grade 2 and grade 0respectively. Radiography revealed osteophytes or subchondral cystic lesions on the right and left stifle joints. Osteoarthrosis (OA) scores for the right and left stifle joints were 20 and 12 respectively. Combination of surgery and implantation of autologous adipose tissue derived mesenchymal t stem cells (aAT-MSCs) was determined with informed consent. 1 x 10^6 aAT-MSCs suspended in PBS and 0.6mL of hyaluronic acid were injected in the right stifle joint postoperatively. Osteoarthrosis scores and the lameness grade for the right and left stifle joints were 19 and 13and 0 and 01 9 months after treatment, respectively ,and 14 and 15and 0 and 0 five years after treatment, respectively.

This case report shows radiographical evidence of a decrease in osteophytes and subchondral cystic lesions on the stifle joint with OA after aAT-MSCs injection.


Key words: Autologous adipose tissue-derived stem cellsstifle jointosteoarthrosisdog.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s