Pharmacodynamics – Great tables!

Yeah! Love these tables!
From Elsevier’s Rapid Review Pharmacology
Drug Receptors and Mechanisms of Signal Transduction

Receptor Ligand Mechanism Time
G Protein–Coupled Receptors (GPCRs)
α 1-Adrenergic receptors
  • Phenylephrine (agonist)
  • Prazosin (antagonist)
Activation of phospholipase C Sec
α 2-Adrenergic receptors
  • Clonidine (agonist)
  • Yohimbine (antagonist)
Inhibition of adenylyl cyclase; open ion channels Sec
β-Adrenergic receptors
  • Isoproterenol (agonist)
  • Propranolol (antagonist)
Stimulation of adenylyl cyclase Sec
Muscarinic receptors
  • Pilocarpine (agonist)
  • Atropine (antagonist)
Activation of phospholipase C Sec
Ligand-Gated Ion Channels
GABA A receptors
  • Benzodiazepines (agonists)
  • Flumazenil (antagonist)
Chloride flux Msec
Nicotinic ACh receptors
  • Nicotine (agonist)
  • Tubocurarine (antagonist)
Sodium flux Msec
Membrane-Bound Enzymes
Insulin receptors Insulin Activation of tyrosine kinase Min
Cytokine receptors Interleukin-2 Activation of tyrosine kinase Min
Cytoplasmic Receptors
Cytoplasmic guanylyl cyclase Nitroglycerin (NO) Activation of guanylyl cyclase Min
Nuclear receptors
Steroid receptors Adrenal and gonadal steroids Activation of gene transcription Hr
Thyroid hormone receptors Thyroxine Activation of gene transcription Hr
Major G Protein Signaling Pathways

αType Function * Coupled Receptors
s Stimulates adenylyl cyclase (↑ cAMP) Dopamine (D 1), epinephrine (β 1, β 2), glucagon, histamine (H 2), vasopressin (V 2)
i Inhibits adenylyl cyclase (↓ cAMP) Dopamine (D 2), epinephrine (α 2)
q Stimulates phospholipase C (↑ IP 3, DAG) Angiotensin II, epinephrine (α 1), oxytocin, vasopressin (V1), Histamine (H 1)
Effects of Elevated cyclic adenoside monphosphate (cAMP) in Various Tissues

Tissue/Cell Type Hormone Increasing cAMP Major Cellular Response
Adipose tissue Epinephrine ↑ Hydrolysis of triglycerides
Adrenal cortex Adrenocorticotropic hormone (ACTH) Hormone secretion
Cardiac muscle Epinephrine, norepinephrine ↑ Contraction rate
Intestinal mucosa Vasoactive intestinal peptide, epinephrine Secretion of water and electrolytes
Kidney tubules Vasopressin (V 2receptor) Resorption of water
Liver Glucagon, epinephrine
  • ↑ Glycogen degradation
  • ↑ Glucose synthesis
Platelets Prostacyclin (PGI2) Inhibition of aggregation
Skeletal muscle Epinephrine ↑ Glycogen degradation
Smooth muscle (bronchial and vascular) Epinephrine
  • Relaxation (bronchial)
  • Vasodilation (arterioles)
Thyroid gland Thyroid-stimulating hormone Synthesis and secretion of thyroxine

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