Primary site of folate absorption is:
A. Proximal jejunum.
Which of the following test is most helpful in diagnosis of thalassemia :
A. serum iron and iron binding capacity
B. bone marrow iron stain
C. hemoglobin electrophoresis
All can be associated with Sickle Cell Anemia EXCEPT:
A. vasoocclusive cresis
C. bleeding disease
D. organ damage
E. chest Syndrome
F. Aplastic cresis
All of the following common finding in Acute Lymphocytic leukemia EXCEPT:
C. marked elevation in WBCs
D. Gum hypertrophy
The Philadelphia chromosome observed in which one of the following leukemia:
A. chronic myeloid leukemia
B. Acute Lymphocytic Leukemia
Thrombocytopenia can be all of the following EXCEPT:
D. Essential thrombocytopenia
All of the following features of Multiple Myeloma EXCEPT:
A. Pathological fracture
B. Increase plasma abnormal cells in bone marrow
C. Increase peak serum of monoclonal protein in electrophoresis
D. Increase Hemoglobin level
Hodgkin’s Disease the most common histological subtype is:
A. Lymphocytic predominant
B. Mixed Cellularity
C. Nodular sclerosing
D. Lymphocyte depleted
In which of the following Hematological disorders the polymerase chain reaction is helpful:
A. Megaloblastic anemia
B. Hemolytic anemia
C. Iron deficiency anemia
D. Hemolytic malignancy
Following is a myeloid marker
a. CD 3
b. CD 10
c. CD 13
d. CD 19
Most common type of congenital leukemia
Which of the following statements pertaining to leukemia is correct?
A. Blasts of acute myeloid leukemia are typically sudan black negative
B. Blasts of acute lymphoblastic leukemia are typically myloperoxidase positive
C. Low leucocyte alkaline phosphatase score is characteristically seen in blastic phase of chronic myeloid leukemia
D. Tartarate resistant acid phosphatase positivity is typically seen in hairy cell leukemia
Correct answer : D. Tartarate resistant acid phosphatase positivity is typically seen in hairy cell leukemia
In sickle cell disease:
a. the disorder is a single gene disorder T
b. carrier has normal blood test F
c. the abnormalities involves the alpha chain of the globin
d. there is absence of HbA T
e. sickle cell crisis does not affect carrier of the disease F
– In sickle cell, HbA is replaced by HbS
– HbS has a valene in place of glutamic acid in the sixth amino acid residue of
beta globulin molecule
Which of the following statements on lymphoma is not true?
a) A single classification system for Hodgkin’s disease (HD) is almost universally accepted
b) HD more often tends to remain localized to a single group of lymph nodes and spreads by contiguity
c) Several types of non Hodgkin’s lymphoma (NHL) may have a leukemic phase
d) In general follicular (nodular)NHL has worse prognostic compared to diffuse NHL
Hodgkin’s Lymphoma most serious subtype is nodular sclerosis. What type of
cell is needed to diagnose HL?
– Jonny fontaine cells
– Reed-Sternberg cells
– John Wayne cells
Acute myeloid leukemia without maturation would show what myeloblast
– CD34, CD33, CD15
– CDs and 8-tracks
Acute B-cell lymphoblastic leukemia / lymphoma would show what type of cell markers?
– ALL of the above, except the question…I know, ridiculous!
Typical symptoms of ALL/lymphomas (and AML) include all of the following except
– sudden onset
– nerve palsies
What is seen mostly in mostly in children, where there are chromosomal changes,
, hyperploidy, Philadelphia chromosome*, translocations (9;22)
SIGNIFICANT response to chemo: 90% remission,
– Acute lymphoblastic leukemia
– Chronic LL
Examples of mutations in neoplastic proliferations of WBC for acute
leukemia are all except
– Transcription factor
– Tyrosine kinase
All acute leukemias suppress normal hematopoesis, e.g., have
– decrreased perforin
In the case of ___________,
there is an intimate concurrence with malignant lymphomas
In the case of __________, the primary
process is marrow and peripheral blood, but can involve any
organ or tissue which receives blood.
– neutrophilic precursors
Kostmann syndrome is genetic, congenital, eg, severe neutropenia.
What does this affect?
What number is the danger zone for
inadequate production / increased desctruction?
In HIV infection (and autoimmune), you would be likely to see
– leukopenia, after glucocorticoids or cytotoxic drug treatment
– high CD4 count
Another bane for B12 is _______. In what anemia would you see
– Cobalamin, pernicious anemia
– Thiamine, Barrett’s esophagus
Lack of what causes anemia in B12 deficiency?
B12 combines with intrinsic factor in the gastric mucosa and is absorbed
– in the cecum
– in the terminal illeum
– in the duodenum
How about folate?
– proximal jejunum (yup, it’s the one at the top!)
As for enlarged RBC, megaloblasts are in the bone marrow,
what are in the peripheral blood?
As for giant WBC, what are seen in the marrow, peripheral blood?
– Blastocysts, lymphophils
– giant metamyelocytes, hypersegmented neutrophils
Megaloblastic anemias (non-hemolytic, MCV > 94, macrocytes in peripheral smear)
are due to impaired DNA synthesis and are
– anemias of B12 and Folate deficiency
– none of the above
In HGB-S disease (sickle cell), you may see
autosplenectomy, but what infections would you become
more susceptible to?
– pneumococcus, Hem. influ, salmonella, osteomyelitis
Normal HGB is α2β2: β-chain defects (Val->Glu)
Reduced hemoglobin “sickles” in homozygous
8% of American blacks are heterozygous
– scickle cell anemia
The sickle cell trait –
Sickle cell trait (or sicklemia)
describes a condition in which a person has one abnormal allele of the hemoglobin
beta gene (is heterozygous), but does not display the severe symptoms of
sickle cell disease that occur in a person who has two copies of that
allele (is homozygous).
Those who are heterozygous for the sickle cell allele produce both normal and abnormal hemoglobin (the two alleles are codominant with respect to the actual
concentration of hemoglobin in the circulating cells).