– Osteosarcoma is a malignant tumour of:
a. osteoblasts
b. osteoclasts

What is the 2nd most common primary malignant bone tumour?
a. Osteosarcoma
b. Osteochondroma

What is the normal function of BRCA1/BRCA2?
a. Regulation of RNA repair
b. Regulation of DNA repair

What type of cells are proliferating in Osteosarcoma (Osteogenic Sarcoma)?
a. osteoclasts
b. osteoblasts (osteoid secretion tumour)

What age group is commonly affected by secondary Osteosarcoma (Osteogenic Sarcoma)?
a. > 65 y/o
b. > 70 y/o

What is MOA of Etoposide?
a. Causes double stranded DNA breaks through DNA Topoisomerase
b. Causes single stranded RNA breaks through DNA Topoisomerase

What type of cancer chemotherapy is Cyclophosphamide?
a.  Adjuvant
b. CCNS Alkylating agent

Which enzyme involved with DNA replication creates a single- or double-stranded break in the DNA double helix to add or remove supercoils?
a. DNA Topoisomerase
b. RNA DNA Topoisomerase

T or F:
Methotrexate is an anti-metabolite cancer therapy

What is the MOA of the antineoplastic Cisplatin?
a. Cross-linking of DNA
b. Cross-linking of RNA

Which bone cancer has an increased risk of occurring in Paget Disease of Bone?
a. osteosarcoma
b. osteochondroma

What age group is commonly affected by Osteosarcoma (Osteogenic Sarcoma)?
a. Bimodal distribution (10-20 y/o and > 65 y/o)
b. Bimodal distribution (15-30 y/o and > 70y/o)





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