– Osteosarcoma is a malignant tumour of:
What is the 2nd most common primary malignant bone tumour?
What is the normal function of BRCA1/BRCA2?
a. Regulation of RNA repair
b. Regulation of DNA repair
What type of cells are proliferating in Osteosarcoma (Osteogenic Sarcoma)?
b. osteoblasts (osteoid secretion tumour)
What age group is commonly affected by secondary Osteosarcoma (Osteogenic Sarcoma)?
a. > 65 y/o
b. > 70 y/o
What is MOA of Etoposide?
a. Causes double stranded DNA breaks through DNA Topoisomerase
b. Causes single stranded RNA breaks through DNA Topoisomerase
What type of cancer chemotherapy is Cyclophosphamide?
b. CCNS Alkylating agent
Which enzyme involved with DNA replication creates a single- or double-stranded break in the DNA double helix to add or remove supercoils?
a. DNA Topoisomerase
b. RNA DNA Topoisomerase
T or F:
Methotrexate is an anti-metabolite cancer therapy
Which bone cancer has an increased risk of occurring in Paget Disease of Bone?
What age group is commonly affected by Osteosarcoma (Osteogenic Sarcoma)?
a. Bimodal distribution (10-20 y/o and > 65 y/o)
b. Bimodal distribution (15-30 y/o and > 70y/o)